Macrophage M2 Reprogramming
Idiopathic Pulmonary Fibrosis · LNP-mRNA IRF4/STAT6/KLF4 forces pro-regenerative macrophage state
Mechanism
LNP-mRNA IRF4/STAT6/KLF4 forces pro-regenerative macrophage state
Development stage
Preclinical
Evidence level
Level 3 (Cross-domain)
Developer
Multiple
Overview
Axolotl macrophages are obligatory for regeneration. Human alveolar macrophages stuck in SPP1+ pro-fibrotic state. Novel cross-species insight.
Explore related
Medical disclaimer. This page summarizes research about Macrophage M2 Reprogramming for information only. It is not medical advice. Verify approval status and evidence with the FDA and a pulmonologist.